![]() X., Binvignat, O., Auladell, C., & Camins, A. Olloquequi, J., Cornejo-Córdova, E., Verdaguer, E., Soriano, F. Fluid therapy in neurointensive care patients: ESICM consensus and clinical practice recommendations. ![]() Oddo, M., Poole, D., Helbok, R., Meyfroidt, G., Stocchetti, N., Bouzat, P., … & Citerio, G. Glutamate release and neuronal damage in ischemia. Secondary Gains: Advances in Neurotrauma Management. September 2016/ for Management of Severe TBI 4th_Edition.pdf. Reviewed for evidence–based integrity and endorsed by the American Association of Neurological Surgeons and the Congress of Neurological Surgeons. Guidelines for the Management of Severe Traumatic Brain Injury (4th ed.). Metabolic acetate therapy for the treatment of traumatic brain injury. The use of ademol compared to amantadine sulfate and 0.9% NaCl solution was accompanied by a more significant decrease in the activity of lipid peroxidation and oxidative degradation of proteins and an improvement in the level of antioxidant enzymes in damaged brain of animals with TBI (p<0.05). In the course of the experiment, it was found that treatment of rats with TBI ademol leads to a decrease in the activity of lipid peroxidation and oxidative degradation of proteins (p<0.05) and promotes the normalization of the activity of antioxidant enzymes in cells of traumatically damaged brain (p<0.05). Wilcoxon, Fisher's angular transformation at p <0,05. We used the parametric criterion of t-Student, non-parametric criterion of W. The pseudoperated animals and control group received a 0.9% solution of NaCl and amantadine sulfate at a dose of 2 ml/kg and 5 mg/kg i/v. The therapeutic effect of ademol on model TBI was evaluated with a 2 mg/kg dose. The experimental TBI model of severe severity was caused by the action of a carbon dioxide flow under pressure created using a gas balloon pneumatic gun. The experiments were performed on 28 white male rats weighing 160-190 g. The aim of this study was to evaluate the effect of ademol compared with amantadine sulfate and 0.9% NaCl solution on the course of oxidative stress in the brain of TBI rats. An important measure of intensive care in patients with traumatic brain injury (TBI) is the use of pharmacotherapeutic agents with antioxidant properties.
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